本法系用气相色谱法（通则0521）（（通则0521））测定酒剂或酊剂等含乙醇制剂中甲醇的含量。除另有规定外，按下列方法测定。
第二法（填充柱法）
色谱条件与系统适用性试验 用直径为0.18~0.25mm的二乙烯苯-乙基乙烯苯型高分子多孔小球作为载体；柱温125℃。理论板数按甲醇峰计算应不低于1500；甲醇峰、乙醇峰与内标物质各相邻色谱峰之间的分离度应符合规定。
传统的填充柱想要达到1000以上的理论塔板数，非常困难，为了解决这一难题，
浩瀚色谱（山东）应用技术开发有限公司，研制出《药典0521甲醇的理论塔板数测定专用色谱柱》测定药典中甲醇，丙酮，乙醇等的理论塔板数，甲醇高达30000以上，效果不错。
在安捷伦，岛津，赛默飞，瓦里安，布鲁克，PE等仪器上均可获得满意的结果。
此柱为浩瀚色谱，经过特殊处理而生产的
此柱为浩瀚色谱的特色产品
名称：不锈钢填充柱
规格：3m*1/8
型号：HH-TBS-III
应用：药典0521理论塔板数的测定
适用于：安捷伦，岛津，赛默飞，瓦里安，布鲁克，PE
This method uses gas chromatography (General Rule 0521) to determine the content of methanol in ethanol containing preparations such as alcoholic beverages or tinctures. Unless otherwise specified, determine according to the following methods.
The second method (filling column method)
The chromatographic conditions and system suitability test uses porous polymer beads of diethylbenzene ethylethylethylethylbenzene type with a diameter of 0.18-0.25mm as the carrier; The column temperature is 125 ℃. The number of theoretical plates calculated based on the methanol peak should not be less than 1500; The separation degree between adjacent chromatographic peaks of methanol peak, ethanol peak, and internal standard substance should comply with regulations.
It is very difficult for traditional packed columns to achieve a theoretical tray number of over 1000. To solve this problem
Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. has developed a specialized chromatographic column for determining the theoretical plate number of methanol, acetone, ethanol, etc. in Pharmacopoeia 0521. The column has been used to determine the theoretical plate number of methanol, acetone, ethanol, etc. in Pharmacopoeia 0521, with methanol reaching over 30000 and achieving good results.
Satisfactory results can be obtained on instruments such as Agilent, Shimadzu, Thermo Fisher, Varian, Bruker, PE, etc.
This column is produced through special processing for the Haohan chromatography
This column is a characteristic product of Haohan Chromatography
Name: Stainless Steel Filled Column
Specification: 3m * 1/8
model: HH-TBS-III
Application: Determination of theoretical tray number in Pharmacopoeia 0521
Applicable to: Agilent, Shimadzu, Thermo Fisher, Varian, Brooke, PE
滕州市浩瀚色谱仪器技术服务有限公司
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